Associate Director, Clinical Supply Chain, Cambridge, MA

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. Your impact We are seeking a proactive, self-driven, highly organized, and entrepreneurial Clinical Supply Chain colleague to lead end-to-end clinical trial material (CTM) planning, vendor management, packaging, labeling, inventory management, and global distribution operations. Reporting directly to the Head of Early Development, you will serve as the clinical supply authority within a lean Pharmaceutical Sciences & CMC Manufacturing team, acting as a direct partner to Clinical Operations and the larger Clinical Development organization. As part of an AI-first company, you will help us reimagine how we bring new medicines to patients. This role is designed for growth. As our pipeline advances, you will be the foundational architect of our clinical supply operations - scaling systems, processes, and vendor networks to support future clinical studies in different modalities and therapeutics areas. Operating within an agile model, you will execute operations through external clinical packaging and labeling vendors, central/regional depots, specialized temperature-controlled chain couriers, and Interactive Response Technology (IRT/RTSM) providers. Internally, you will bridge between drug manufacturing with Clinical Operations for clinical trial execution. What you will do Clinical Supply Planning & Execution • Dynamic Demand Forecasting: Build and maintain flexible clinical supply models tailored to the unpredictable pace of clinical trials, ensuring uninterrupted patient dosing while minimizing drug waste. • Rapid-Response Resupply: Manage flexible investigational product fulfillment and site replenishment strategies to support dynamic protocol milestones, dose adjustments, and study demand fluctuations across participating trial sites. • Pharmacy Manuals & Site Support: Collaborate with internal colleagues and Clinical CROs to author and review the Investigational Product (IP) Handling and Pharmacy Manuals, establishing clear site-level guidance for drug storage, handling, accountability, and dose preparation, reconciliation, and destruction. Packaging, Labeling & Distribution Logistics • Packaging & Label Design: Direct secondary packaging, blinding/kitting strategies, and label generation for clinical trial supplies, ensuring regulatory compliance with applicable regional and global standards and regulations. • Depot & Logistics Management: Select and manage central and regional clinical depots; oversee qualified domestic shipping lines, secure chain-of-custody protocols, and specialty courier operations. • Understand the latest retest/expiry dating for clinical supplies by coordinating with Analytical Development to get the latest shelf life on clinical supplies to ensure recovery/recalls can be done without interrupting or delaying the clinical study. • Temperature Monitoring & Excursions (TEs): Implement continuous temperature monitoring solutions across shipments and depot storage. • Triage temperature excursions in real time, partnering with Analytical Chemistry and Quality Assurance to assess stability impact and execute rapid product disposition. • Accountability, Reconciliation & Destruction: Direct end-of-study IP reconciliation, returns, and authorized destruction workflows across trial sites and depots in compliance with cGMP/GCP and ICH standards. • Direct qualified domestic and international shipping vendors and distribution strategies , QP release coordination , import/export permits/license requirements, depot networks and VAT planning and recovery. Clinical CRO, IRT/RTSM & Clinical Operations Partnership • Clinical CRO Alignment: Serve as the primary clinical supply chain liaison to Clinical CROs, synchronizing supply readiness with clinical timelines. • IRT/RTSM System Implementation: Partner with Clinical Operations and IRT providers to design system functional specifications, supply buffer strategies, reorder triggers, predictive resupply logic, and User Acceptance Testing (UAT). • Site Activation Readiness: Track country- and site-level regulatory approvals, import/export