Senior Finance Business Partner (Clinical), Cambridge, MA

• Business & Financial Partnering: Serve as the primary finance partner for the Clinical Development team. Provide strategic thought partnership to support delivery of clinical portfolio objectives. • Budgeting and Forecasting: You will guide end-to-end clinical budgeting, forecasting, and resource planning. You will build and maintain bottoms-up financial models for clinical studies (e.g. tracking site activations, patient enrolment, pass-through costs etc) • Vendor Oversight & Advisory: Partner with Clinical Operations and Procurement during RFP processes to evaluate, benchmark, and negotiate budgets with clinical vendors. Support vendor onboarding, invoice review/approval, P2P processes and troubleshooting. • Reporting & Process Improvement: Deliver regular variance analysis and continuously enhance financial reporting and workflows to support portfolio growth. Develop robust and efficient accruals processes. • Cambridge Finance Lead: As our first finance hire in Cambridge, MA, you will act as the Cambridge site finance lead and partner closely with the site leadership team.

• Collaborative Partner: Someone who builds trusting relationships, acts as a strategic thought partner and can bridge between science and finance. • Proactive Problem Solver: A curious, resourceful mindset with the drive to resolve issues pragmatically and optimise our playbook and processes. • Detail and Process Oriented: Highly organized and meticulous with clinical trial budgets. Capable of balancing multiple operational workflows whilst maintaining high standards. • Independent and Growth-Oriented: A self-starter, always looking for ways to streamline processes and leverage technology to increase efficiency.

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enriched by the incredible power of machine learning. A future in which diseases are curtailed or cured starting with better and faster drug discovery. Come and be part of an interdisciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring and collaborative culture. The world we want tomorrow is the one we’re building today. It starts with the culture at this company. It starts with you. About Iso Isomorphic Labs (IsoLabs) was launched in 2021 to advance human health by building on and beyond the Nobel-winning AlphaFold system. Since then, our interdisciplinary team of drug discovery experts and machine learning specialists has built powerful new predictive and generative AI models that accelerate scientific discovery at digital speed. Our name comes from the belief that there is an underlying symmetry between biology and information science. By harnessing AI’s powerful capabilities, we can use it to model complex biological phenomena to help design novel molecules, anticipate how drugs will perform and develop innovative medicines to treat and cure some of the world’s most devastating diseases. We have built a world-leading drug design engine comprising AI models that are capable of working across multiple therapeutic areas and drug modalities. We are continually innovating on model architecture and developing cutting-edge capabilities to advance rational drug design. Every day, and with each new breakthrough, we’re getting closer to the promise of digital biology, and achieving our ambitious mission to one day solve all disease with the help of AI. Your impact As our Senior Finance Business Partner (Clinical Development), you will serve as the dedicated financial strategic partner to our growing Clinical Development team. You will be a critical contributor to the success of this team and will be responsible for financial management of all clinical-related work. This is a new role supporting our team based in Cambridge, MA. You will have the opportunity to bring financial thought leadership and rigor to key stakeholders as Iso progresses more medicines into the clinic as we march towards our mission to Solve All Disease. About you • Collaborative Partner: Someone who builds trusting relationships, acts as a strategic thought partner and can bridge between science and finance. • Proactive Problem Solver: A curious, resourceful mindset with the drive to resolve issues pragmatically and optimise our playbook and processes. • Detail and Process Oriented: Highly organized and meticulous with clinical trial budgets. Capable of balancing multiple operational workflows whilst maintaining high standards. • Independent and Growth-Oriented: A self-starter, always looking for ways to streamline processes and leverage technology to increase efficiency. What you will do • Business & Financial Partnering: Serve as the primary finance partner for the Clinical Development team. Provide strategic thought partnership to support delivery of clinical portfolio objectives. • Budgeting and Forecasting: You will guide end-to-end clinical budgeting, forecasting, and resource planning. You will build and maintain bottoms-up financial models for clinical studies (e.g. tracking site activations, patient enrolment, pass-through costs etc) • Vendor Oversight & Advisory: Partner with Clinical Operations and Procurement during RFP processes to evaluate, benchmark, and negotiate budgets with clinical vendors. Support vendor onboarding, invoice review/approval, P2P processes and troubleshooting. • Reporting & Process Improvement: Deliver regular variance analysis and continuously enhance financial reporting and workflows to support portfolio growth. Develop robust and efficient accruals processes. • Cambridge Finance Lead: As our first finance hire in Cambridge, MA, you will act as the Cambridge site finance lead and partner closely with the site leadership team. Skills and qualifications Essential: • Clinical Finance Expertise: Direct experience managing clinical development finances (CROs, sites) and FP&A/partnering within biotech, pharma, or life sciences. Deep experience in financial analysis including building and maintaining robust patient-driven financial models. • Education & Analytical Skills: Degree in Finance, Accounting, Economics, or other quantitative field. • Communication & Rigor: Clear executive-level communicator for both technical and non-technical audiences. Strong attention to detail and ability to manage competing priorities in a fast-paced environment. • Teamwork and collaboration: Proven track record in business partnering and excellence in stakeholder management. • AI to drive efficiency: Experience in utilizing LLMs and other AI to drive efficiency Nice to have: • Professional accounting qualification (e.g., ACA, ACCA, CIMA, CPA, or equivalent). • Experience using Google Workspace (Sheets, Slides etc) . • Experience managing financial systems (e.g. ERP, procurement). Culture and values We are guided by our shared values. It's not about finding people who think and act in the same way. These values help to guide our work and will continue to strengthen it. Thoughtful Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day. Brave Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less. Determined Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neithe